β-D-fucoside, (3β,4α,16β)-13,28-epoxy-16,23-
saikosaponin a
CAS: 20736-09-8
Molecular Formula: C42H68O13
β-D-fucoside, (3β,4α,16β)-13,28-epoxy-16,23- - Names and Identifiers
β-D-fucoside, (3β,4α,16β)-13,28-epoxy-16,23- - Physico-chemical Properties
| Molecular Formula | C42H68O13 |
| Molar Mass | 780.98 |
| Density | 1.163～1.168 g/ml |
| Melting Point | 225～232℃ (dec.) |
| Boling Point | 893.7±65.0 °C(Predicted) |
| Specific Rotation(α) | (EtOH)+46 |
| Flash Point | 494.3°C |
| Solubility | DMSO (Slightly), Methanol (Slightly, Sonicated), Pyridine (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| Color | White to Off-White |
| pKa | 12.83±0.70(Predicted) |
| Storage Condition | Hygroscopic, Refrigerator, under inert atmosphere |
| Stability | Hygroscopic |
| Refractive Index | 1.571～1.574 (20/D) |
| Physical and Chemical Properties | Light yellow crystals, soluble in water, dilute alcohol, difficult to dissolve in benzene, ether, chloroform, from the aerial part of bupleurum. |
β-D-fucoside, (3β,4α,16β)-13,28-epoxy-16,23- - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
β-D-fucoside, (3β,4α,16β)-13,28-epoxy-16,23- - Reference
| Reference Show more | 1. Xin Guo Zhao Xintong Li Wen et al. Effects of decocting Bupleurum at different times on the content and pharmacodynamics of saikosaponin in Wuchaihu Decoction [J]. Journal of Changchun University of Traditional Chinese Medicine 2018(4):641-644. 2. Ning Yanmei Yang Xiujuan Chen Hui Zhang Jinbao Yang Tao Ren Yuan. Determination and comparison of total saponins in Bupleurum products processed by different proportions of turtle blood [J]. Journal of Chinese Veterinary Medicine 2019 38(05):9-13. 3. Qiu Yun, Su Jian, Pang Xue, et al. Effects of Different Processing Methods on the Contents of Saikosaponin A and D in Bupleurum chinense [J]. Journal of Hunan University of Traditional Chinese Medicine 2016 (Phase 2):51-53. 4. Pang Xue, Liao Nian, Zhou Yiqun, et al. Effects of Different Processing Methods on Saikosaponin Content in Bupleurum chinense [J]. Shi Zhen Guo Yi Chinese Medicine 2016(12):2906-2908. 5. Liao Nian, Pang Xue, Zhou Yiqun, et al. Optimization of Orthogonal Test Method for Bran Simmering Process of Bupleurum chinense chinense [J]. Shi Zhen Guo Yi Chinese Medicine 2017(05):96-98. 6. Guo Tailin, Li Dandan, Zhang Hui. Study on Fingerprint of Bupleurum HPLC-ELSD from North and South [J]. Chinese Folk Medicine 2020 029(006):19-24. 7. Li Ying, Jiao Qian, Zhang Tiantian, et al. Study on Ecological Suitability Zoning of Bupleurum in Hebei Province Based on Topographic Factors [J]. Chinese Journal of Traditional Chinese Medicine, 2017, 042(022):4402-4407. 8. Cao Xue, Cai Guangzhi, Zhao Ling, et al. Grade Evaluation of Beicaihu Decoction Pieces Based on Compound Mass Constant [J]. Chinese Journal of Experimental Prescription, 2018(18). 9. Hu Dongrong, Xuan Zhengzheng, Xie Wei, et al. Establishment and Content Determination of High Performance Liquid Fingerprint of Chaihu Shugan Decoction [J], 2017(6):1310-1314. 10. Zhu Shuanglong, Duan Huiquan, Liu Yingfu, et al. Neuroprotective Effect and Mechanism of Saikosaponin A on Acute Spinal Cord Injury in Rats [J]. Chinese Journal of Repair and Reconstruction Surgery, 2017, 031(007):825-829. 11. Zhu Shuanglong, Chen Xuyi, Duan Huiquan, Liu Yingjie, Sun Zhonglei, Xu Yunqiang. Experimental study on the effect of saikosaponin a on the expression of inflammation after acute spinal cord injury in rats [J]. Journal of Tianjin Medical University, 2017,23(04):300-303. 12. Pan Long, Niu Junli, Bu Dengpan, Du Hong, Cheng Jianbo, Sun Xianzhi, Wang Xiumin, Qin Junjie, Yuan Yaoming, Zhang Xingkai. Effects of saikosaponin on fermentation parameters and bacterial quantity in vitro [J]. Journal of grassland industry, 2015,24(06):85-91. 13. Liao Nian, Pang Xue, Zhou Yiqun, et al. Optimization of Bran Stiffing Process of Bupleurum Chinensis by Orthogonal Test [J]. Chinese Pharmacist, 2017, 020(004):738-740. 14. Zhao Xintong, Xin Guo, Xin Yu, etc. Effect of Decocting Time on Contents of Saikosaponin A and Saikosaponin D in Bupleurum [J]. Ginseng Research, 2017. 15. Yang Mengling, You Pengtao, He Lishan, et al. Analysis of Pharmacokinetics of 8 Active Components in Plasma of Gastric Ulcer Model Rats after Oral Administration of Modified Xiaochaihu Granules Based on UPLC-MS/MS [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 43(18). 16. Huang Xiang, Chen Fenglian, Cao Cheng, et al. HPLC-ELSD all-component fingerprint to study the changes of chemical composition before and after compatibility of Shugan Lipi Recipe [J]. Chemical and Biological Engineering 2020 037(001): 59-64. 17. Li Zhuangzhuang, Zhang Jing, Zhao Shaozhe, etc. Fingerprint and chemometrics are combined to optimize the water extraction process of Chaihu Guizhi granules [J]. Chinese patent medicine, 2018, v.40(08):199-203. 18. Tian D-D, Wang W, Wang H-N, Sze SCW, Zhang Z-J. Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats. Molecules. 2016; 21(6):696. https://doi.org/10.3390/molecules 19. Wang, Wei, Dan-Dan Tian, and Zhang-Jin Zhang. "In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism." Molecules 21.5 (2016): 597.https://doi.org/10.3390/molecules21050597 20. [IF = 4.411] Wei Wang et al."In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism." Molecules. 2016 May;21(5): 597 21. [IF = 4.411] Dan-Dan Tian et al."Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, radix Bupleuri, or Fructus Gardeniae in Rats." Molecules. 2016 Jun;21(6):696 22. [IF = 3.216] Yu Hong et al."Saikosaponin A modulates remodeling of Kv4.2-mediated A- type voltage-gated potassium currents in rat chronic temporal lobe epilepsy." Drug Des Dev Ther. 2018; 12: 2945-2958 23. [IF = 3.205] Zhuangzhuang Li et al."Simultaneous quantification of fifteen compounds in rat plasma by LC-MS/MS and its application to a pharmacokinetic study of Chaihu-Guizhi decoction." J Chromatogr B. 2019 Jan;1105:15 24. [IF = 5.81] Cui Lihua et al."Chaihu Guizhi Ganjiang Decoction Ameliorates Pancreatic Fibrosis via JNK/mTOR Signaling Pathway." Front Pharmacol. 2021 Jun;0:1369 25. [IF = 4.534] Jikun Du et al."Saikosaponin-A induces apoptosis of cervical cancer through mitochondria- and endoplasmic reticulum stress-dependent pathway in vitro and in vivo: involvement of PI3K/AKT signaling pathway." Cell Cycle. 2021;20(21):2221-2232 26. [IF = 4.36] Xiaojing Zhang et al."A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and inuce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway." J Ethnopharmacol. 2022 Jan;283:114742 27. [IF=3.205] Jie Tang et al."Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."J Chromatogr B. 2021 Aug;1179:122827 28. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 29. [IF=2.977] An-rong Wang et al."Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway."Behav Brain Res. 2021 Apr;403:113138 |
β-D-fucoside, (3β,4α,16β)-13,28-epoxy-16,23- - Reference Information
| biological activity | Saikosaponin A is the main active ingredient from Bupleurum chinense, which can up-regulate the expression of LXRα and has effective anti-inflammatory activity. |
| uses | saikosaponin a has sedative, antiviral, immune regulation, liver and kidney protection and anti-tumor effects. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has various pharmacological effects such as anticonvulsant, antiepileptic and anticell adhesion. |
Last Update：2024-04-09 21:54:55
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